Ludmila Livshits

Professor
Ludmila Livshits

українська версія
english version

Birth date: December 13, 1951. Education: 1969-1975, Kiev State Shevchenko University, Biological department. Academic degree: Ph.D. (1991), Sci.D. (2001). Academic status: Professor (2004). Affiliation: Institute of Molecular Biology and Genetics, National Academy of Sciences of Ukraine. Position: Head of the Department of Human Genomics. Scientific awards: Ministry of Education and Science award (2004). Major research interests: human molecular genetics, genome mutations, human genome diversity and evolution. Scientific papers: 157.

On L.A. Livshits own initiative and direct participation the molecular genetic researches of hereditary deseases of monogenic nature and molecular genetic heterogeneity analysis of regional population in Ukraine were started. First the data about the nature, origin and mechanisms of mutant genes expansion, that cause hereditary deseases with early infant mortality and high invalidization:(cystic fibrosis, pheniketonuria, spinal muscular atrophy, muscular Duchenne dystrophy, fragile X-chromosome syndrome, Charcot-Marie-Tooth desease, Friedreich`s ataxy, hereditary hemochromatosis, Huntington`s desease, haemophilia А and hereditary corneal dystrophies) and also men and women infertility in Ukrainian population were obtained. The results concerning spectrum and distribution of certain mutation types and their association with desease phenotype were received. First the new mutation that causes the cystic fibrosis development, spread only among Slavic population, was characterized. Molecular genetic methods for DNA diagnostics (including prenatal diagnostics) of abovementioned deseases were developed and are being applied to health protection practice in Ukraine.

The studies of the inherited mutations in children of Chernobyl cleanup workers is an important research direction of L.A. Livshits. The priority-driven information about the children genofond status on DNA-sequence level was obtained and the mechanisms of mutagenic effect of irradiation during gametogenesis were characterized. First in Ukraine the collection of more than 3000 samples of leucocyte DNA was created. This collection consists of DNA collected from high risk family members of the most spread hereditary deseases and the members of Chernobyl cleanup workers families, as well the healthy population from different regions of Ukraine.

Tel.: 380 (44) 526 5597. Fax: 380 (44) 526 0759. Home tel.: 380 (44) 235 0709. E-mail: livshits@imbg.org.ua.

Selected publications:

  1. Pampukha VM, Drozhyna GI, Livshits LA. TGFBI gene mutation analysis in families with hereditary corneal dystrophies from Ukraine. Ophthalmologica. 2004 Nov-Dec; 218(6): 411-4. PMID: 15564760 [PubMed - indexed for MEDLINE]
  2. Verbenko DA, Kekeeva TV, Pogoda TV, Khusnutdinova EK, Mikulich AI, Kravchenko SA, Livshits LA, Bebyakova NA, Limborska SA. Allele frequencies for D1S80 (pMCT118) locus in some East European populations.J Forensic Sci. 2003 Jan; 48(1): 207-8. PMID: 12570233 [PubMed - indexed for MEDLINE
  3. Limborska SA, Balanovsky OP, Balanovskaya EV, Slominsky PA, Schadrina MI, Livshits LA, Kravchenko SA, Pampuha VM, Khusnutdinova EK, Spitsyn VA. Analysis of CCR5Delta32 geographic distribution and its correlation with some climatic and geographic factors. Hum Hered. 2002; 53(1): 49-54. PMID: 11901272 [PubMed - indexed for MEDLINE]
  4. Kravchenko SA, Slominskii PA, Bets LA, Stepanova AV, Mikulich AI, Limborskaia SA, Livshits LA. Polymorphism of the STR-locus of Y chromosomes in Eastern Slavs in three populations from Belorussia, Russia and the Ukraine] Genetika. 2002 Jan; 38(1): 97-104. Russian. PMID: 11852801 [PubMed - indexed for MEDLINE]
  5. Popova SN, Slominsky PA, Pocheshnova EA, Balanovskaya EV, Tarskaya LA, Bebyakova NA, Bets LV, Ivanov VP, Livshits LA, Khusnutdinova EK, Spitcyn VA, Limborska SA. Polymorphism of trinucleotide repeats in loci DM, DRPLA and SCA1 in East European populations. Eur J Hum Genet. 2001 Nov; 9(11): 829-35. PMID: 11781699 [PubMed - indexed for MEDLINE]
  6. Livshits LA, Malyarchuk SG, Kravchenko SA, Matsuka GH, Lukyanova EM, Antipkin YG, Arabskaya LP, Petit E, Giraudeau F, Gourmelon P, Vergnaud G, Le Guen B. Children of chernobyl cleanup workers do not show elevated rates of mutations in minisatellite alleles. Radiat Res. 2001 Jan; 155 (1 Pt 1): 74-80. PMID: 11121218 [PubMed - indexed for MEDLINE]
  7. Rosser ZH, Zerjal T, Hurles ME, Adojaan M, Alavantic D, Amorim A, Amos W, Armenteros M, Arroyo E, Barbujani G, Beckman G, Beckman L, Bertranpetit J, Bosch E, Bradley DG, Brede G, Cooper G, Corte-Real HB, de Knijff P, Decorte R, Dubrova YE, Evgrafov O, Gilissen A, Glisic S, Golge M, Hill EW, Jeziorowska A, Kalaydjieva L, Kayser M, Kivisild T, Kravchenko SA, Krumina A, Kucinskas V, Lavinha J, Livshits LA, Malaspina P, Maria S, McElreavey K, Meitinger TA, Mikelsaar AV, Mitchell RJ, Nafa K, Nicholson J, Norby S, Pandya A, Parik J, Patsalis PC, Pereira L, Peterlin B, Pielberg G, Prata MJ, Previdere C, Roewer L, Rootsi S, Rubinsztein DC, Saillard J, Santos FR, Stefanescu G, Sykes BC, Tolun A, Villems R, Tyler-Smith C, Jobling MA. Y-chromosomal diversity in Europe is clinal and influenced primarily by geography, rather than by language. Am J Hum Genet. 2000 Dec; 67(6): 1526-43. Epub 2000 Nov 9. PMID: 11078479 [PubMed - indexed for MEDLINE]
  8. Livshits LA, Kravchenko SA. Cystic Fibrosis in Ukraine: age, origin and tracing of the delta F508 mutation. Gene Geogr. 1996 Dec; 10(3): 219-27. PMID: 9263776 [PubMed - indexed for MEDLINE]
  9. Baranov VS, Ivashchenko TE, Gorbunova VN, Voronina OV, Gaitskhoki VS, Gol'tsov AA, Kaboev OK, Shvarts EI, Berlin IuA, Livshits LA, et al. [Allele polymorphism of the DNA loci MET, D7S8, D7S23, linked to the cystic fibrosis gene in some populations of the USSR, in high risk families and in cystic fibrosis patients] Genetika. 1991 Jan; 27(1): 113-21. Russian. PMID: 2037248 [PubMed - indexed for MEDLINE]
  10. T. D"rk, M. Macek Jr., F. Mekus, : M. Nechiporenko, L. Livshits, et al. Characterization of a novel 21-kb deletion, CFTRdele2, 3 (21 kb), in the CFTR gene: a cystic fibrosis mutation of Slavic origin common in Central and East Europe // Hum. Genet. 2000; 106 (3): 259-268.
  11. Livshits LA, Malyarchuk SG, Kravchenko SA, Matsuka GH, Lukyanova EM, Antipkin YG, Arabskaya LP, Petit E, Giraudeau F, Gourmelon P, Vergnaud G, Le Guen B. Children of chernobyl cleanup workers do not show elevated rates of mutations in minisatellite alleles // Radiat. Res. 2001; 155 (1 Pt 1): 74-80.